周荣斌教授

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2020-05-27

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实验室主页：http://lirst.ustc.edu.cn/

周荣斌 教授，博导，2011年进入免疫所。长江学者、国家杰青获得者。生命科学与医学部副部长、基础医学院执行院长。主持基金委创新群体、科技部重点研发计划等项目。任CellMolImmunol编委、中国免疫学会常务理事、青年工作委员会主任委员和安徽省免疫学会副理事长。以第一/通讯作者在Nature、Cell、NatRevImmunol、NatImmunol、Immunity等发表论文20余篇。第一完成人获国家自然科学二等奖、中国优秀青年科技人才奖、中国青年科技奖、谈家桢生命科学创新奖等。

主要研究兴趣：无菌性炎症中的固有免疫识别、调控机制和干预策略研究。

近期发表论文：

1.Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Cell. 2015 Jan 15;160(1-2):62-73.

2.ApoC3: an 'alarmin' triggering sterile inflammation. Gong T, Zhou R*. Nat Immunol. 2020 Jan;21(1):9-11.

3.Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S*, Jiang W*, Zhou R*. Nat Immunol. 2019 Dec;20(12):1681-1691.

4.RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. Nat Immunol. 2014 Dec;15(12):1126-33.

5.DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Gong T, Liu L, Jiang W*, Zhou R*.Nat Rev Immunol. 2020 Feb;20(2):95-112.

6.Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z*, Tschopp J, Zhou R*. Immunity. 2013 Jun 27;38(6):1154-63.

7.Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W*, Deng X*, Zhou R*. J Exp Med. 2017 Nov 6;214(11):3219-3238.

8.TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. Lang X, Tang T, Jin T, Ding C, Zhou R*, Jiang W*. J Exp Med. 2017 Feb;214(2):459-473.

9.Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. Jiang W, Wang X, Ze